Editorial: First There Was One, Then Two . . . Why More 11β-Hydroxysteroid Dehydrogenases?
نویسندگان
چکیده
منابع مشابه
11β-Hydroxysteroid Dehydrogenases in the Regulation of Tissue Glucocorticoid Availability
The regulation of tissue-specific actions of glucocorticoids (GCs) goes far beyond the effects of the fluctuation of their circulating levels and can be controlled by local intracellular en‐ zymes. In the past few years, evidence is being gathered not only on the relevance of such enzymes to GC physiological actions but also on their involvement in the pathophysiology of certain chronic disease...
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Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and...
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The metabolic syndrome describes a clustering of risk factors-visceral obesity, dyslipidaemia, insulin resistance, and salt-sensitive hypertension-that increases mortality related to cardiovascular disease, type 2 diabetes, cancer, and non-alcoholic fatty liver disease. The prevalence of these concurrent comorbidities is ~ 25-30% worldwide, and metabolic syndrome therefore presents a significan...
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An ab initio study of the addition of successive water molecules to the amino acid l-alanine in both the nonionized (N) and zwitterionic (Z) forms are presented. The main focus is the number of waters needed to stabilize the Z form and how the solvent affects conformational preference. The solvent is modeled by ab initio electronic structure theory, the EFP (effective fragment potential) model,...
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The history of hydrogen — the element that fills the world as we know it — consists of a most dramatic set of events. Hydrogen and helium atoms emerged a measly 379,000 years after the Big Bang. As the hot, dense plasma of protons, electrons and photons that was the universe began to cool and expand, electrons and protons gathered to form atoms. Four hundred million years later stars — such as ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1997
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.138.12.5669